Tokyo, Nov. 26 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059870) titled 'Left Ventricular Strain Versus Ejection Fraction for Risk Stratification Before TAVI: A Comprehensive Meta-Analysis' on Nov. 25.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - Saga University

Condition: Condition - Aortic Stenosis Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Left ventricular global longitudinal strain (LVGLS) is a sensitive marker of subclinical systolic dysfunction in aortic stenosis, where left ventricular ejection fraction (LVEF) often remains preserved despite advanced myocardial impairment. Although several studies have suggested that LVGLS predicts outcomes after transcatheter aortic valve implantation (TAVI), existing evidence has been constrained by modest sample sizes, heterogeneous methods, and inconsistent multivariable adjustment. A comprehensive assessment of the independent prognostic value of LVGLS - directly compared with LVEF - has not been performed. To evaluate the prognostic impact of preprocedural LVGLS on mortality and adverse clinical outcomes after TAVI and to determine whether LVGLS provides greater prognostic discrimination than LVEF. Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - This study targeted patients who underwent TAVI and examined the preoperative LVGLS and its prognostic predictive ability. Key exclusion criteria - Studies that did not treat LVGLS as a continuous variable, or studies with overlapping patient populations, were excluded from this research.

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 01 Month 01 Day Anticipated trial start date - 2025 Year 01 Month 01 Day Last follow-up date - 2026 Year 11 Month 25 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068373

Disclaimer: Curated by HT Syndication.