Clinical Trial: Prospective observational study on the relationship between diaphragmatic action potentials and extubation outcomes during ventilatory management (Japan)

Tokyo, July 26 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058595) titled 'Prospective observational study on the relationship between action potentials emitted by the diaphragm during ventilatory management and the possibility of extubation' on July 25.

Study Type: Observational

Primary Sponsor: Institute - Nara Medical University

Condition: Condition - Respiratory failure requiring ventilator management in the intensive care unit Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Continuous evaluation of Edi (Electrical activity of the diaphragm) and its relationship to VFD28 (ventilator free days at 28days) Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 20 years-old

Gender - Male and Female Key inclusion criteria - 1. 18 years of age or older 2. Patients who started ventilator management by oral intubation 3. Cases in which muscle relaxants are administered at the start of ventilation 4.Can be managed in Assist/Control Mode 5. Ventilated with Puritan Bennett980/840, SERVO-U Ventilator, Hamilton C6 6.Patients expected to survive more than 24 hours Key exclusion criteria - 1. patients who were intubated upon ICU admission 2. pregnant women 3. patients whose diaphragmatic function is not expected to recover (e.g., end-stage neuromuscular disease) 4. Artificial respiration for more than 8 hours prior to admission to the ICU 5. patients who have been in the ICU within the past month 6. patients who have undergone invasive positive pressure ventilation for non-surgical reasons within the past month 7. whose Code is DNAR 8. lack of equipment such as Servo series, NAVA Catheter, etc. 8. 9. absence of investigator 10. failure to obtain research consent 11. drug intoxication 12. brain death Target Size - 80

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 06 Month 23 Day Date of IRB - 2025 Year 06 Month 23 Day Anticipated trial start date - 2025 Year 06 Month 24 Day Last follow-up date - 2027 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066020

Disclaimer: Curated by HT Syndication.