Tokyo, Dec. 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059823) titled 'Quantitative Evaluation of Otolith and Gravity Perception Function Using Visually-Induced Tilt Illusion' on Dec. 1.

Study Type: Interventional

Study Design: Basic Design - Single arm Randomization - Non-randomized Blinding - Open -no one is blinded Control - Self control

Primary Sponsor: Institute - Institute of Science Tokyo

Condition: Condition - Healthy control, cases with PPPD Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The presence or absence of centrifugal eye movement changes due to alterations in gravity perception will be verified by comparing tilted visual backgrounds presented via a HeadMounted Display that either induce or fail to induce gravity perception. This will allow for the quantification of the sense of dizziness at the spatial orientation level independent of peripheral vestibular function. Furthermore, we will investigate the potential for quantifying gravity perception function in patients with Persistent PosturalPerceptual Dizziness who complain of persistent unsteadiness resulting from increased visual dependence in spatial orientation formation. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Research participants will wear VR goggles. Inside the goggles, backgrounds with defined verticality (such as buildings) and backgrounds without defined verticality (such as outer space) will be displayed. These backgrounds will be tilted, and the resulting torsional eye rotation angle (or ocular counter-roll) will be measured. The tilt angles will be 60, 90, 120degrees.The eye movements will be digitized and recorded in real-time.

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Healthy adult subjects (with no history of dizziness, unsteadiness, or otologic disease) and PPPD patients. Key exclusion criteria - Under 18 Target Size - 60

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 12 Month 01 Day Anticipated trial start date - 2025 Year 12 Month 01 Day Last follow-up date - 2030 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068393

Disclaimer: Curated by HT Syndication.