Tokyo, Dec. 5 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059964) titled 'Randomized Controlled Trial Comparing Methods of Providing Moisturizers to Prevent Hand Eczema in Ward Nurses' on Dec. 4.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Open -but assessor(s) are blinded Control - No treatment

Primary Sponsor: Institute - Nara Medical University

Condition: Condition - hand eczema Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - Healthcare workers perform hand hygiene more frequently than non-healthcare workers, resulting in a higher incidence of hand eczema, which often becomes chronic and difficult to manage. Among them, ward nurses have particularly high hand hygiene demands in their daily practice, and previous studies have reported that they have a higher incidence of hand eczema and are more prone to severe disease.

Topical moisturizers are widely recommended as a preventive measure for hand eczema. However, in actual clinical settings, they are often underused due to barriers such as inconvenience and the lack of a habitual moisturizing routine.

In this study, ward nurses will be assigned to one of three groups: (1) individual distribution of moisturizers, (2) placement of moisturizers within the ward, and (3) no provision of moisturizers. The impact of each approach on hand eczema will be compared and evaluated.

The aim of this study is to clarify the effect of topical moisturizers on hand eczema and to identify the most effective method of providing moisturizers. Ultimately, this research seeks to establish practical and feasible strategies for the prevention and management of hand eczema in healthcare settings. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - Moisturizers will be individually distributed to the intervention group. Each participant will receive one box containing ten 25 g tubes and will use them during working hours. The frequency and timing of application will not be specified and will be left to the discretion of each participant. The intervention period will be 12 weeks, and the weight of the moisturizer will be measured at 6 and 12 weeks to assess the amount used. Interventions/Control_2 - Moisturizers will be placed in the wards for the intervention group. Pump containers filled with approximately 300 g of moisturizer will be placed in shared areas within the target wards (e.g., nurse stations and washstands) to allow free use. The intervention period will be 12 weeks, and the weight of the moisturizer will be measured at 6 and 12 weeks to assess the amount used.

Eligibility: Age-lower limit - 20 years-old

Gender - Male and Female Key inclusion criteria - Based on the results of a hand eczema survey conducted on all staff working at our hospital from July 14 2025 to July 25 2025, six wards were selected as the target. Among the nurses working in the designated wards, those who provide consent to participate in the study (25 to 30 nurses per ward) will be selected. Key exclusion criteria - Participants who are known in advance to be unable to continue participation until the end of the 12 week observation period due to resignation or leave of absence Participants who are judged at the time of obtaining consent to have insufficient ability to understand the purpose and content of the study Participants whom the principal investigator judges to be inappropriate for participation in this study Target Size - 165

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 09 Month 22 Day Date of IRB - 2025 Year 11 Month 28 Day Anticipated trial start date - 2025 Year 12 Month 04 Day Last follow-up date - 2026 Year 03 Month 19 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068554

Disclaimer: Curated by HT Syndication.