Tokyo, Jan. 11 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059984) titled 'Noninvasive Assessment of Pulmonary Vascular Resistance Using Right-Ventricular IRT in Idiopathic Pulmonary Fibrosis' on Jan. 10.
Study Type:
Observational
Primary Sponsor:
Institute - Nippon Medical School
Condition:
Condition - Idiopathic Pulmonary Fibrosis
Classification by malignancy - Others
Genomic information - NO
Objective:
Narrative objectives1 - To determine whether right ventricular isovolumetric relaxation time (IRT) serves as a useful noninvasive marker of pulmonary vascular resistance (PVR) and pulmonary vascular resistance index (PVRI) in patients with idiopathic pulmonary fibrosis (IPF).
Basic objectives2 - Others
Eligibility:
Age-lower limit - 20
years-old
= 20 years
Diagnosis of idiopathic pulmonary fibrosis (IPF) based on ATS/ERS/JRS/ALAT guidelines
Transthoracic echocardiography and right heart catheterization performed during the same hospitalization under stable conditions
No acute exacerbation, infection, hospitalization, or corticosteroid escalation within the previous 4 to 8 weeks
Antifibrotic therapy, if used, must be stable for at least 4 weeks before evaluation
Complete hemodynamic data including mPAP, PAWP, and cardiac output
Doppler waveforms for IRT and PAAT that are suitable for analysis
CPFE cases are excluded (mild emphysema 15 mmHg
Interstitial lung diseases other than IPF
Chronic thromboembolic disease confirmed by CT pulmonary angiography or ventilation perfusion scanning
Atrial fibrillation or significant arrhythmias
Acoustic windows inadequate for Doppler evaluation
Use of pulmonary hypertension targeted therapy before echocardiography or right heart catheterization
Missing essential echocardiographic or hemodynamic data
Target Size - 180
Recruitment Status:
Recruitment status - No longer recruiting
Date of protocol fixation - 2015 Year 03 Month 01 Day
Date of IRB - 2020 Year 10 Month 01 Day
Anticipated trial start date - 2015 Year 04 Month 01 Day
Last follow-up date - 2025 Year 11 Month 30 Day
To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068591
Disclaimer: Curated by HT Syndication.
