Tokyo, Aug. 15 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000062552) titled 'CT-based blood flow and structural analysis to identify rupture-prone regions of abdominal aortic aneurysm' on Aug. 11.

Study Type: Observational

Primary Sponsor: Institute - Sapporo Medical University

Condition: Condition - Abdominal aortic aneurysm (including ruptured abdominal aortic aneurysm) Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To retrospectively verify whether the high-risk regions (e.g., peak wall stress sites) estimated by computational fluid dynamics (CFD) and finite element analysis (FEA) of pre-rupture CT images spatially correspond to the actual rupture site in patients with ruptured abdominal aortic aneurysm. Basic objectives2 - Others

Eligibility: Age-lower limit - 20 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1) Patients diagnosed with rupture of an abdominal aortic aneurysm (ruptured abdominal aortic aneurysm). 2) Patients in whom CT including the abdomen was performed before the rupture, with available DICOM data of sufficient quality (e.g., slice thickness 2 mm or less) for computational fluid dynamics (CFD) and finite element analysis (FEA). 3) Patients in whom the actual rupture site can be identified on CT obtained at the time of rupture and/or by operative findings. 4) Patients aged 20 years or older at diagnosis. Key exclusion criteria - 1) Patients without pre-rupture CT, or those whose image quality is inadequate for analysis. 2) Patients with aneurysms other than true abdominal aortic aneurysm, such as infectious or inflammatory aneurysm, traumatic aortic injury, aneurysm associated with aortic dissection, or anastomotic pseudoaneurysm. 3) Patients in whom the rupture site cannot be identified from imaging or operative findings. 4) Patients who had undergone repair of the abdominal aortic aneurysm (endovascular aneurysm repair or open graft replacement) before the rupture. 5) Patients (or their legal representatives) who declined the use of their clinical and imaging data for this study. Target Size - 30

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 08 Month 11 Day Anticipated trial start date - 2026 Year 09 Month 01 Day Last follow-up date - 2028 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000071603

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