Tokyo, July 24 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058547) titled 'Systematic Review of the Functional Effects of GABA on Skin Elasticity' on July 24.

Study Type: Others,meta-analysis etc

Primary Sponsor: Institute - Japan Clinical Trial Association

Condition: Condition - healthy adult men and women Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - The objective of this study was to investigate whether oral administration of GABA enhances skin elasticity in healthy adult males and females, in comparison to a placebo Basic objectives2 - Efficacy

Eligibility: Age-lower limit - 18 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Participants The study targeted healthy adult men and women as participants. Given the absence of standardized clinical criteria to distinguish between healthy and diseased individuals based on skin elasticity, no numerical thresholds were applied to define skin health. Instead, individuals were excluded from the healthy cohort if they had received a medical diagnosis, undergone dermatological procedures beyond routine skincare, or used pharmaceutical products. Furthermore, individuals with any diagnosed medical conditions, minors, pregnant women, and lactating women were also excluded from participation.

Intervention The intervention consisted of the oral intake of a food product containing gamma-aminobutyric acid (GABA). Data were collected at three time points: 4 weeks, 8 weeks, and 12 weeks after the start of intake. Participants were categorized into three groups based on their daily GABA intake: less than 30 mg, 30-99 mg, and 100 mg or more. Products with unclear GABA content were excluded from the analysis.

Control The control condition was defined as the oral intake of food products that do not contain gamma-aminobutyric acid (GABA). In principle, products containing GABA or other ingredients known to affect the study outcomes were excluded. However, studies involving non-intake or products containing only trace amounts of such ingredients-judged unlikely to influence the outcomes-were permitted to be included in the control group Key exclusion criteria - Exclude trials that do not meet the selection criteria, such as those including individuals with diseases.

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2025 Year 07 Month 23 Day Anticipated trial start date - 2025 Year 07 Month 24 Day Last follow-up date - 2026 Year 07 Month 24 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000066812

Disclaimer: Curated by HT Syndication.