Tokyo, Aug. 2 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000058658) titled 'The clinical differences based on the subtype of primary aldosteronism: Phase 2' on July 31.

Study Type: Observational

Primary Sponsor: Institute - Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

Condition: Condition - Primary aldosteronism Classification by malignancy - Others Genomic information - YES

Objective: Narrative objectives1 - The objective of this study is to elucidate a method for differentiating between various phenotypes of primary aldosteronism without the use of adrenal venous sampling, with a focus on the clinical characteristics of primary aldosteronism. Additionally, while the gold standard for the definitive diagnosis of primary aldosteronism currently involves inpatient load tests, this study aims to identify a more convenient method for distinguishing between essential hypertension and primary aldosteronism by comparing and analyzing their clinical features. Since the reference values for load tests used in the diagnosis of primary aldosteronism differ across countries, the phenotypes diagnosed may also vary slightly. By conducting an international collaborative study, this research will contribute to the identification of more widely applicable diagnostic markers. Basic objectives2 - Others

Eligibility: Age-lower limit - Not applicable Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1. Patients who were diagnosed with primary aldosteronism and essential hypertension at Nihon University Itabashi Hospital (January 1, 2006 - January 1, 2030).

2. Patients who were diagnosed with primary aldosteronism and essential hypertension at Institute of Science Tokyo Hospital, Affiliated Hospital of Chongqing Medical University, Monash University, and Hudson Institute of Medical Research (January 1, 2006 - January 1, 2030). Key exclusion criteria - Patients who refused to participate in this study and the investigator determined to be unsuitable for study Target Size - 1000

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 07 Month 09 Day Date of IRB - 2025 Year 07 Month 09 Day Anticipated trial start date - 2025 Year 07 Month 09 Day Last follow-up date - 2030 Year 07 Month 01 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067076

Disclaimer: Curated by HT Syndication.