Tokyo, Nov. 1 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059530) titled 'An investigation into the diagnostic value of screening all older colorectal cancer patients for defects in cancer's DNA repair function (MMR/MSI testing)' on Nov. 1.

Study Type: Observational

Primary Sponsor: Institute - Asahikawa Medical University

Condition: Condition - Colorectal Cancer Classification by malignancy - Malignancy Genomic information - YES

Objective: Narrative objectives1 - To clarify the prevalence and clinicopathological characteristics of Mismatch Repair Deficiency (MMRd) in elderly patients who have undergone resection for colorectal cancer. Basic objectives2 - Others

Eligibility: Age-lower limit - 20 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - Diagnosis and Treatment: Patients diagnosed with Colorectal Cancer (CRC) who underwent surgical or endoscopic resection at Asahikawa Medical University Hospital. Required Test: Patients who have been assessed for high-frequency microsatellite instability (MSI-H) via either MSI testing or Mismatch Repair (MMR) protein Immunohistochemistry (IHC). Age: Patients must have been 20 years of age or older at the time of diagnosis. Observation Period: Patients who underwent surgery on or after January 1, 2013. Exclusions: All stages, disease sites, and genders are included. (i.e., No restrictions on stage, site, or gender.) Key exclusion criteria - Lack of Diagnostic Data: Cases where pathological tissue samples necessary for MMR/MSI status evaluation are unavailable or technically inadequate for testing. Loss to Follow-up: Cases where prognosis data (DFS/OS) cannot be reliably traced, making primary outcome evaluation impossible. Non-Adenocarcinoma: Cases with a pathological diagnosis other than adenocarcinoma (e.g., adenoma, carcinoid, GIST, lymphoma). Non-Colorectal Origin: Cases where the primary tumor site is not colorectal (e.g., metastatic tumor from another organ). Withdrawal of Consent: Cases where the patient or their proxy has formally withdrawn consent (opt-out) for the secondary use of their clinical data. Target Size - 750

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2024 Year 05 Month 29 Day Date of IRB - 2024 Year 05 Month 29 Day Anticipated trial start date - 2024 Year 05 Month 29 Day Last follow-up date - 2026 Year 03 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000068090

Disclaimer: Curated by HT Syndication.