Tokyo, Sept. 16 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059087) titled 'The Effect of Pelvic Sex Differences on Skeletal Structure and Joint Alignment' on Sept. 16.

Study Type: Interventional

Study Design: Basic Design - Single arm Randomization - Non-randomized Blinding - Open -no one is blinded Control - Self control

Primary Sponsor: Institute - Gunma University

Condition: Condition - Healthy adult males, healthy adult females Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This study aims to investigate the influence of pelvic sex differences on joint alignment in healthy adults. It has been reported that the pelvis exhibits sex differences, and that women tend to have a larger quadriceps angle (the angle formed by connecting the attachment points of the quadriceps muscles). This larger angle may contribute to a greater physiological knee valgus angle. Given that the quadriceps angle originates from the pelvis, which is known to show sex differences, we hypothesized that a larger pelvis would correlate with a greater physiological knee valgus angle. Furthermore, the incidence of anterior cruciate ligament injuries and knee osteoarthritis is reportedly higher in women. While some reports suggest that physical differences between men and women may explain this sex-based disparity in injury rates, the specific details remain unclear. Therefore, this study focuses on the alignment between the pelvis and the knee joint to clarify how pelvic sex differences influence knee valgus alignment. Basic objectives2 - Others

Intervention: Interventions/Control_1 - Twenty-five female and twenty-five male subjects will be enrolled. The intervention period for each subject will be one day, with a duration of one hour. Subjects will maintain the following postures for 30 seconds each: bilateral stance, unilateral stance, and unilateral stance (pelvis horizontal position). Information on joint space and joint angles will be collected. Following this, muscle strength measurements of the hip abductor muscle group will be performed twice for each leg (right and left).

Eligibility: Age-lower limit - 18 years-old = Gender - Male and Female Key inclusion criteria - 1) Healthy adults aged 18 years or older but under 40 years old, affiliated with Gunma University School of Medicine or Gunma University Graduate School of Health Sciences. 2) Individuals capable of maintaining a single-leg stance for 30 seconds or longer. 3) Individuals who consent to participate in the study. Consent is deemed given upon signing the consent form after receiving an explanation using the informed consent document. 4) Posters describing the research outline will be displayed. Individuals who see these posters and voluntarily express their willingness to participate in the study. Posters will be displayed at the following locations: - Motion Analysis Laboratory, 6th Floor, Shared Facilities Building, Gunma University School of Medicine - ADL Training Room, 1st Floor, West Building, Department of Health Sciences, Gunma University School of Medicine - Prosthetics and Orthotics Room, 1st Floor, West Building, Department of Health Sciences, Gunma University School of Medicine - Physical Therapy Training Room, 2nd Floor, West Building, Department of Health Sciences, Gunma University School of Medicine - Classroom 6, 2nd Floor, West Building, Department of Health Sciences, Gunma University School of Medicine - Classroom 2, 1st Floor, Central Building, Gunma University School of Medicine Recruitment will continue until the end of October 2025. Recruitment will close earlier if the target number of cases is reached before that date. Key exclusion criteria - 1) Individuals with fractures, sprains, or muscle/ligament injuries. 2) Individuals who do not consent to camera filming for three-dimensional motion analysis. Target Size - 50

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 08 Month 15 Day Date of IRB - 2025 Year 08 Month 15 Day Anticipated trial start date - 2025 Year 09 Month 14 Day Last follow-up date - 2025 Year 10 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067589

Disclaimer: Curated by HT Syndication.