Clinical Trial: The G-PMI Score: A Composite of the Geriatric Nutritional Risk Index and Psoas Muscle Index for Predicting Long-Term Outcomes After Esophagectomy in Male Patients with Esophageal Cancer- A Retrospective Cohort Study (Japan)

Tokyo, May 24 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061670) titled 'A retrospective cohort study of the G-PMI score for predicting long-term outcomes after curative-intent esophagectomy for esophageal cancer' on May 23.

Study Type: Observational

Primary Sponsor: Institute - Hokkaido University Hospital

Condition: Condition - Esophageal cancer Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - The objective of this study is to develop and evaluate the G-PMI score, a composite index combining the Geriatric Nutritional Risk Index (GNRI) and the psoas muscle index (PMI), in patients who underwent curative-intent esophagectomy for esophageal cancer. The study aims to assess the prognostic stratification ability of the G-PMI score for overall survival and disease-free survival, with particular attention to sex differences in the prognostic relevance of GNRI and PMI. Basic objectives2 - Others

Eligibility: Age-lower limit - 18 years-old

Gender - Male and Female Key inclusion criteria - 1.Patients with primary esophageal cancer who underwent curative-intent esophagectomy at Hokkaido University Hospital between January 2010 and December 2024. 2.Patients with available preoperative laboratory and anthropometric data required for calculation of the Geriatric Nutritional Risk Index. 3.Patients with available preoperative CT images required for measurement of the psoas muscle index. Key exclusion criteria - 1.Patients who did not undergo surgery with curative intent. 2.Patients who underwent surgery for malignancies other than primary esophageal cancer. 3.Patients with missing data required for calculation of the Geriatric Nutritional Risk Index or measurement of the psoas muscle index. Target Size - 216

Recruitment Status: Recruitment status - Completed Date of protocol fixation - 2024 Year 10 Month 02 Day Date of IRB - 2024 Year 10 Month 02 Day Anticipated trial start date - 2024 Year 10 Month 02 Day Last follow-up date - 2026 Year 05 Month 04 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070563

Disclaimer: Curated by HT Syndication.