Tokyo, June 5 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061803) titled 'The Impact of Hospital Surgical Volumes on Short-Term Outcomes Following Brain Tumor Surgery from a Nationwide Database in Japan' on June 5.

Study Type: Observational

Primary Sponsor: Institute - Yokohama City University

Condition: Condition - Central Nervous System Tumors Classification by malignancy - Malignancy Genomic information - NO

Objective: Narrative objectives1 - The literature suggests that patients with brain tumors show better prognoses when treated at hospitals with high surgical volumes, and this is considered one of the key factors contributing to favorable outcomes. However, previous studies have primarily focused on estimating conditional effects, and to the best of our knowledge, there are no reports estimating the average causal effect within the population when surgical volume is treated as an intervention variable. In this study, we will conduct an epidemiological study using the DPC (Diagnosis Procedure Combination) database-a nationwide database in Japan-and a methodology called "Target Trial Emulation", which simulates an ideal randomized controlled trial (target trial). The objective of this study is to estimate the causal effect between intervention strategies that altering the number of brain tumor surgeries performed at medical institutions and short-term postoperative outcomes for brain tumors by clearly defining ideal trial conditions and emulating them using observational study data. Basic objectives2 - Others

Eligibility: Age-lower limit - Not applicable Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - 1. Observation period: Patients who (1) have DPC data for hospitalizations between April 2018 and March 2023, based on the date of discharge; (2) underwent specific surgeries for brain tumors (defined by seven types of K-codes: K1691, K1692, K154-3, K169-2, K 169-3, K 171-22, K171-21) during the observation period; (3) classified under ICD-10 codes Cxx and Dxx, which indicate neoplasms (tumors); (4) were all ages. Key exclusion criteria - None. (We will cope with multiple imputation for missing value of covariates in analysis.) Target Size - 27000

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2026 Year 06 Month 04 Day Date of IRB - 2025 Year 11 Month 21 Day Anticipated trial start date - 2026 Year 06 Month 05 Day Last follow-up date - 2026 Year 06 Month 06 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000070722

Disclaimer: Curated by HT Syndication.