Tokyo, Oct. 9 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000059346) titled 'The Impact of Postoperative Tranexamic Acid on Knee Swelling After Total Knee Arthroplasty' on Oct. 9.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Double blind -all involved are blinded Control - No treatment

Primary Sponsor: Institute - Takagi Hospital Oume Knee Surgery Center

Condition: Condition - Knee osteoarthritis Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - This study aims to evaluate whether a 14-day course of postoperative tranexamic acid (TXA) can effectively alleviate swelling. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - A group of 50 patients undergoing primary unilateral total knee arthroplasty (TKA) between September 2025 and October 2026, who will receive postoperative tranexamic acid administration. Interventions/Control_2 - A control group of 50 patients undergoing primary unilateral total knee arthroplasty (TKA) between September 2025 and October 2026, who will not receive postoperative tranexamic acid administration.

Eligibility: Age-lower limit - 50 years-old = Gender - Male and Female Key inclusion criteria - Patients will receive tranexamic acid (TXA) at a dose of 1000 mg twice daily from postoperative day 1 to day 14. For patients with an estimated glomerular filtration rate (eGFR) between 30 and 60, the dose will be adjusted to 500 mg twice daily. Patients with eGFR > 60 will receive 1000 mg twice daily. Key exclusion criteria - Patients with an estimated glomerular filtration rate (eGFR) below 30. Target Size - 100

Recruitment Status: Recruitment status - Open public recruiting Date of protocol fixation - 2025 Year 10 Month 09 Day Date of IRB - 2025 Year 08 Month 02 Day Anticipated trial start date - 2025 Year 10 Month 09 Day Last follow-up date - 2027 Year 05 Month 31 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000067406

Disclaimer: Curated by HT Syndication.