Clinical Trial: The effect of anesthetics on postoperative delirium in hip fracture surgery in elderly patients -comparison of remimazolam and desflurane- (Japan)

Tokyo, Feb. 10 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000060630) titled 'The effect of anesthetics on postoperative delirium in hip fracture surgery in elderly patients -comparison of remimazolam and desflurane-' on Feb. 10.

Study Type: Interventional

Study Design: Basic Design - Parallel Randomization - Randomized Blinding - Double blind -all involved are blinded Control - Active

Primary Sponsor: Institute - Japan Community Healthcare Organization Tokuyama Central Hospital

Condition: Condition - hip fractures Classification by malignancy - Others Genomic information - NO

Objective: Narrative objectives1 - To examine whether the use of remimazolam is associated with an increased or decreased incidence of postoperative delirium compared with desflurane in elderly patients undergoing surgery for hip fractures. Basic objectives2 - Efficacy

Intervention: Interventions/Control_1 - remimazolam Interventions/Control_2 - desflurane

Eligibility: Age-lower limit - 65 years-old <= Age-upper limit - Not applicable Gender - Male and Female Key inclusion criteria - the following criteria are in order to meet eligibility requirements for the current study. 1)Patients undergoing surgery for hip fracture during the research period 2)Patients over 65 years or older Key exclusion criteria - Patients who meet any of the following conditions will not be included in this study: 1)Patients with a history of hypersensitivity to remimazolam or desflurane 2)Patients with acute obstructive glaucoma 3)Patients with myasthenia gravis 4)Patients in shock, coma, or acute alcohol poisoning 5)Patients with a history of malignant hyperthermia or a history of malignant hyperthermia in a blood relative 6)Patients who are unable to communicate due to severe mental illness, language impairment, visual impairment, etc. 7)Patients who developed new cerebrovascular disease during the period 8)Patients requiring intensive care management 9)Patients who died within 5 days after surgery Target Size - 600

Recruitment Status: Recruitment status - Preinitiation Date of protocol fixation - 2023 Year 08 Month 16 Day Date of IRB - 2026 Year 02 Month 04 Day Anticipated trial start date - 2026 Year 02 Month 10 Day Last follow-up date - 2030 Year 06 Month 30 Day

To know more, visit https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000069347

Disclaimer: Curated by HT Syndication.