Japan, Feb. 27 -- FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG EV,WESTFALISCHE WILHELMS UNIV MUNSTER has got intellectual property rights for 'METHOD FOR INCREASING YIELD OF OXIDOSQUALENE, TRITERPENE AND/OR TRITERPENOID AND HOST CELL THEREFOR.' Other related details are as follows:
Application Number: JP,2023-202951
Category (FI): C12P7/02,C12N15/31,C12P5/00,C12N15/53,C12N1/19,C12P7/00,C12N9/04
Stage: PROBLEM TO BE SOLVED: To provide: a method of increasing the yield of at least one of oxidosqualene, triterpenes and/or triterpenoids in a modified host cell; each host cell; and use of the host cell for manufacturing the at least one of oxidosqualene, triterpenes and/or triterpenoids.SOLUTION: A method of increasing the yield comprises: modifying a host cell to overexpress a 3-hydroxy-3-methylglutaryl-coenzyme A reductase as well as to overexpress a protein capable of producing at least one of acetoacetyl-CoA, 3-hydroxy-3-methylglutaryl-CoA, mevalonate-5-phosphate, mevalonate-5-pyrophosphate, isopentenyl-5-pyrophosphate, farnesyl-pyrophosphate or dimethylallyl-pyrophosphate; and culturing the same.SELECTED DRAWING: None (Grant)
Filing Date: Nov. 30, 2023
Publication Date: Feb. 28, 2024
The original document can be viewed at: https://www.j-platpat.inpit.go.jp/p0100
Disclaimer: Curated by HT Syndication.
